2020-02-29 00:35 Results presented here show that plasma von Willebrand factor (vWF) is a substrate for factor XIIIa and can be crosslinked to fibrin during gel formation. vWFfibrin crosslinking was studied in
The activation of XIII to XIIIa takes place and the XIIIa is then assayed either by the incorporation of a substrate into the fibrin clot where the amount of substrate incorporated is then measured, or by measuring the amount of ammonia generated when the transglutamidase reaction takes place. Low factor XIII levels have also been factor xiiia substrate
Coagulation Factor XIIIa Substrates in Human Plasma IDENTIFICATION AND INCORPORATION INTO THE CLOT. Camilla Lund Nikolajsen (2011) Human interinhibitor is a substrate for factor XIIIa and tissue transglutaminase. Biochim. Biophys. Acta 1814,
Feb 01, 2013 FXIII (Factor XIII) is a Ca2dependent enzyme which forms covalent (glutamyl)lysine crosslinks between the carboxyamine group of a glutamine residue and the amino group of a lysine residue. Clinical Science Feb 2013, 124 (3); DOI: 10. 1042CS. Share This Article: Copy. Citation Tools, , , Print. Alerts factor xiiia substrate
Triggering the extrinsic coagulation pathway in plasma and using a fluorogenic factor XIIIa (FXIIIa) substrate for continuously monitoring FXIIIa activity, an FXIIIa generation curve is obtained. J. A. ShaferInteractions of factor XIII with fibrin as substrate and cofactor. Biochemistry, 31 (1992), pp KatonaFactor XIII: a coagulation Examining the Substrate Specificity of Factor XIIIa towards Peptide Substrate Models and C Fibrin Domains by Jacob Bell Submitted in partial fulfillment of the requirements for graduation summa cum laude and with Honors. Department of Chemistry University of Louisville March 2013 FXIII (Factor XIII) is a Cadependent enzyme which forms covalent (glutamyl)lysine crosslinks between the carboxyamine group of a glutamine residue and the amino group of a lysine residue. factor xiiia substrate Factor V is a substrate for the transamidase factor XIIIa. In this study, we show that interinhibitor is a substrate for both factor XIIIa and tissue transglutaminase. These enzymes Fibrinogen C( ) to understand Factor XIIIas substrate specificity. Factor. vii XIIIas specificity for each reactive glutamine in C( ) was monitored by the enzyme's ability to crosslink a lysine mimic, glycine ethyl ester (GEE), to the reactive glutamines (Q237, Mar 07, 2014 Coagulation Factor XIIIa Substrates in Human Plasma. (1994) Bovine histidinerich glycoprotein is a substrate for bovine plasma factor XIIIa. Biochem. Biophys. Res. Commun. 200, 7882. 25. Gorman J. J. , Folk J. E. (1984) Structural features of glutamine substrates for transglutaminases. A series of Glu(pNA)containing peptides was designed to determine the activity of the transglutaminase factor XIIIa at 405 nm due to pnitroaniline release. The most suitable substrate properties were found for peptides containing the Glu(pNA) residue in the second position from the N terminus.
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